A novel series of 4-thiazolidinone (4a-j) was synthesized and characterized by means of TLC, melting point and spectral data like IR, 1HNMR & Mass spectroscopy. Synthesized compounds were screened for their antibacterial activity against four different strains like Staphylococcus aureus (NCIM 2079), Bacillus subtilius (NCIM 2708), Pseudomonas aeruginosa (NCIM 2242) and Escherichia coli (NCIM 2685) with standard drug ampicillin while antifungal activity was determined against strains like Candida albicans(NCIM 22491) with standard drug griseofulvin. Screening of antioxidative capacity was based on ability to scavenge free radicals by DPPH (free radical scavenging activity test).The results were compared to standard substance ascorbic acid. The synthesized compounds (4a-j) showed significant antimicrobial & antioxidant activity. Compound 4e exhibited extremely significant antimicrobial activity and compound 4f showed extremely significant antioxidative activity.
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